دکتر سید محمد جزایری

دکتر سید محمد جزایری

ایمیل

 jazayerism@tums.ac.ir

رتبه علمی

MD PhD

تحصیلات

• 2003-2004  West of Scotland Specialist Virology Centre (Scientist)
• 1998-2003  University of Glasgow, Institute of Virology (PhD degree)
• 1983-1991  Shahid-Beheshti University of Medical Science (MD degree)
• 1978-1982  Ferdousi Secondary School (secondary school diploma)

دستاورد ها و افتخارات

• International Records:

1. 158 hepatitis B virus core gene sequences cited in GenBank (the highest number of submitted HBcAg to international database).
2. Hepatitis B virus genotyping based on Core gene sequencing (as an alternative approach to either surface and/or complete genome sequencing).
3. Chairing 12 seminars and 2 international workshops during 2005-2010-Scientific manager of 7th ISACL congress (2014)- International coordinator of Tehran Hepatitis Congress (THC3 to THC6) during 2010-2015 and Congress on innovative technology in lab diagnostics (2016 and coming congress on October 2017). 

• Research Background:

1. 1998-early 2000: my project involved applying FTO.9.1 (Rat hepatoma cell line with a construction contained human Annexin V gene) using category III facility for study of biology of the HBV variants.
2. 1999-2001: I did some works on HBV-positive sera obtained from HBV-infected patients from 14 different countries for HB core gene variation. All sequences submitted to the Genbank.
3. 2000-2003: During the PhD course, I investigated the intracellular distribution of HBcAg correlation with the sequence variation in different phases of chronic infection. Using PCR-based site-direct mutagenesis methods, I have found some exciting results on the effect of core protein mutations on its cellular localization.
4. 2003: Receiving some extracted DNA materials from different population of Pacific islands, HBV genome sequenced and analysed for the study of HBV core gene variability and the pattern of human immigration through South-East Asia.
5. 2003-2004: As a part time scientist, I was involved in direct sequencing of DNA and phylogenetic analysis using different soft wares. As part team work, I had been involved in liaising with other colleagues in the UK regarding hepatitis A, influenza and enterovirus sequence analysis.
6. 2005-2015: As an associate professor, I have been involved in more than 24 national research projects especially on hepatitis B virus.
7. 2015-2019: I am engaged in the application of multiples and highthroughput diagnostic systems for microbial diseases diagnostics. During this period, as the chairman of “National Network for Molecular Diagnosis”, I have been organizing 38 meetings and congresses entitled “Application of Real Time PCR for Infectious Diseases Diagnostics” .
8. 2020-Present: As the director of research center for clinical virology and also, the president of Iranian Network for Research in Viral Diseases, I have been engaged in multiple national research projects on Covid-19 epidemiological and clinical aspects. These projects are still on going.

مقالات

1. Distribution of in vitro expressed HBV core
2. Hepatitis Core gene localises to specific Pacific
3. HBV core sequence: definition of genotype-
4. Virus escape, CTL or B cell epitopes?
5. Differential reactivity of mouse monoclonal anti-
6. Propagation of HBV in a rat hepatoma cell line
7. Identification of Pre S region mutants in (HCC)
8. Phylogenetic analysis of HBV based on Pre-S
9. Sequencing of Surface gene and protein in
10. Hepatitis B virus PreS variant and HCC
11. Genotypes of HBV isolates from Iranian chronic carriers of
12. A new core promoter mutation and premature
13. Characterization of serologic markers of babies
14. Set-up of analytical methods for evaluation of
15. Genotype D Evolution in The Middle East
16. Hepatitis B Virus Origin and Evolution.
17. Hepatitis B Virus Surface Antigen Variants
18. Validation of an in vitro method for Hepatitis B
19. A study of genotype, mutants, and
20. HB genotypes distribution in South Asia –
21. Other views of occult hepatitis B in Hepatitis C
22. Probing rate of YMDD motif mutant in
23. Emergence of hepatitis B virus S gene mutants in
24. HBeAg negativity is not equal to the presence of
25. Identification of Drug Resistant Mutants of HBV
26. Hepatitis B Virus Variants in HBV Mono-
27. Identification of Hepatitis B virus surface antigen
28. Correlation of Hepatitis B Surface Antigen
29. Risk Factors for Early-Onset and Late-Onset
30. HBIG in liver transplantation, an up date
31. Hepatitis B vaccine: Prophylactic, therapeutic
32. HBsAg variants; Diagnostic-escape and
33. Prevalence of HBV Genotypes in Egypt among
34. The Prevalence of Hepatitis B Virus Surface
35. High prevalence of occult hepatitis B virus
36. Drug-related mutations in hepatitis B virus
37. HBsAg variants; common escape issues
38. Mutational Analysis of HBs Ag-positive mothers
39. HBV/HDV co-infection in Iranian carriers with
40. Obscure clinical implication of occult hepatitis B virus
41. Occult Hepatitis B In Clinical Settings
42. HBsAg mutants clustered mainly outside of “a”
43. Mutation “Hot Spot” in Immune Epitope on
44. Hepatitis B virus surface protein mutations cl
45. Hepatitis B virus surface antigen (HBsAg)
46. Host and Viral Factors Influencing Liver Fibrosis
47. Prevalence of Common YMDD Motif Mutations
48. Prospective Study of BK Virus Infection and
49. The Pigeonhole of Occult Hepatitis B
50. Prevalence and molecular analysis of occult
51. Hepatic steatosis: prevalence and host/viral risk
52. Molecular epidemiological study of hepatitis B
53. Surface Protein Mutations in Chronic Hepatitis B
54. Characterization of Overt and Occult Hepatitis B
55. Distribution of Hepatitis B virus surface antigen
56. Controversies regarding the prophylactic options
57. Lamivudine resistance and precore variants in
58. Prevalence of blood-borne viruses among Iranian
59. Prevalence of National Responsiveness to HBV
60. HBV vaccination status and response to hepatitis
61. Appropriate Genotyping of Hepatitis B Virus in
62. Evolution of hepatitis B virus surface gene and
63. Clearance of HBV DNA in immunized children
64. Identification of OBI in Health Care Workers
65. OBI in special group
66. IL-17 and IL-22 genetic polymorphisms in HBV
67. How Hepatitis C Virus Leads to Hepatocellular
68. Molecular analysis of OBI among Iranian Human
69. Mutational analysis of reverse transcriptase and
70. Low prevalence of blood-borne virus infection
71. Prevalence of Cytomegalovirus in Patients with
72. Prevalence of Herpes Simplex Virus Infection in
73. HBsAg mutations related to occult hepatitis B
74. Comparative Analysis and Molecular Structure of
75. Asymptomatic EBV shedding in the urine of
76. Regulatory Network Analysis of Epstein–Barr
77. Sero-Prevalence of Blood borne Tumor Viruses
78. Integrated Analysis of Gene Expression Profiles
79. Transcriptome Analysis of PBMC from Chronic
80. Integrated Analysis of Gene Expression Profiles
81. Transcriptome Analysis of PBMC from Chronic
82. CRF35-AD as the main circulating genotype of
83. Evaluation of HTLV‐1 HBZ and proviral load,
84. Human T-Lymphotropic Virus 1 (HTLV-1)
85. Molecular evolution and phylodynamics of HBV
86. Measurement of serum HBs-Ab levels in Iranian
87. Simultaneous detection of opportunistic viral
88. Molecular Mechanisms Responsible for OBI-
89. High Prevalence of OBI among vaccinated
90. HPV Genotypes concordance Between Iranian
91. An insight to HTLV‑1‑associated myelopathy
92. Influenza species and subtypes circulation
93. Co-detection of Bocavirus and bacteria in a
94. Conformational analysis of HBV surface
95. An insight to HTLV-1-associated HAM/TSP
96. Assessment of miR-181b-5p, miR-23a-3p, CL2
97. High risk genotype distribution HPV
98. Phylogenetic and phylodynamic study of HTLV-
99. Investigation of CTNNB1 gene mutations and
100. Clinical Performance of RT-PCR and Chest
101. Phylogenetic and phylodynamic study of Human
102. Characterization of OBI Infection among Iranian Patients with Behcet’s disease
103. Two independent introductions of SARS-CoV-2 into the Iranian outbreak
104. A multicenter retrospective study of clinical
105. A Comparative Analysis of Clinical Characteristics
106. Detection and Quantification of Hepatitis B Virus
107. Comprehensive high-throughput metaanalysis
108. Multipathogen Detection in Patients with
109. Prevalence of HPV genotypes between outpatients
110. Identifying Potential New Gene Expression-Based

ارائه

• International Conferences (Oral Presentations):

1. 4th to 8 th Iranian Conferences on Gastroenterology and Hepatic Diseases, Tehran, Iran-2004 to 2008. Oral presentations in all years.
2. Tehran Hepatitis Congresses (THC) held in 2009 to 2015 in Tehran. Oral presentations in all years.
3. 1st international congress on Biotechnology, Dubai, 2012.
4. 2nd congress on OBI, Guangzhu, China 2014.
5. 26th ESCMID Congress-Amsterdam 2016.
6. EASL Congress-Barcelona, 2016.

دوره ها

• Courses:

1. Virology workshops on different subjects on molecular biology of RNA and DNA viruses held in Glasgow University as annual meetings (1999 to 2003).
2. Performing research and development projects on different RNA and DNA viruses in clinical virology for two year from June 2003 to June 2004, Gartneval Hospital, Glasgow , UK.
3. Performing a training course on quality control issues important in clinical virology for 3 weeks, 2007, Glasgow, UK.
4. Completing a training course on optimization of Real Time PCR, 2007, Glasgow, UK.
5. A training course on different multiplex systems for viral clinical syndromes using real time PCR, Laboratories Reunis, 2009, Luxembourg.
6. A training course on clinical virology reporting, Sheffield Teaching Hospitals NHS, Northern General Hospital, Sheffield, UK, 2013.
7. A training course on the application of Next Generatioj Sequencing for clinical microbiology, as an ESCMID observership grant, Rome, 2018.

مهارت

• Various aspects of molecular biology, particularly its application in virology:

1. Manual and automated DNA and RNA Extraction
2. PCR (Multiplex real time and standard) & RT PCR
3. Direct Sequencing (for more than 5 years)
4. Cloning (more than 300 Clones have been created during my research work)
5. FACS (Flow Cytometry), Becton Dickinson.
6. Confocal Microscopy, Zeiss LSM 510 software
7. Beckman Culter Automated DNA Sequencer
8. Different soft wares for molecular biological studies (Bioedit, Seq Navigator, TriCone, MEGA, Chromas, EndNote, etc
9. Quality control for molecular diagnostic laboratory.

عضویت

• Professor for Clinical Virology, School of Public Health, Department of Virology, Tehran University of Medical Sciences (TUMS).
• President of Iranian Network for Research in Viral Diseases.
• Director of Research Center for Clinical Virology belonged to TUMS.
• A member of Virology Board in The Ministry of Health.
• Member of National Institute for Medical Research Development (NIMAD)
• Iranian liaison person for European Society for Clinical Microbiology and Infectious Disease (ESCMID).
• Member of Clinical Microbiology and Infection (CMI) Journal Editorial Board.
• Dean of Desk for International Cooperation between TUMS and Italy (DICTI).

زمینه علاقمندی

Clinical Virology , …

کتاب ها

1. SM Jazayeri, WF Carman, P Karayannis, HC Thomas, AJ Zuckerman and TJ Harrison. Hepatitis B Surface Antigen (HBsAg) Variation. In Viral Hepatitis, chapter 14. 2005, Churchill Livingston- London.
2. Daram M and Jazayeri SM. Hepatitis B vaccine; advances and promises. In Vaccine in viral infections. Chapter 2. 2010. Shahid Beheshti University Medical Sciences- Tehran. (Correspondence)
3. Jazayeri SM, Alavian SM, Dindoost P, Thomas HC, Karayiannis P. Molecular variants of hepatitis B surface antigen (HBsAg). In Viral Hepatitis, Chapter 8, 2013, Weily Publishing-London. (Correspondence)
4.  Poortahmesebi V, Alavian SM, Jazayeri SM. Occult Hepatitis B Infection. Chapter 10. Science Press. China, 2015. (Correspondence).